This is entirely possible. The key factor is whether the new role requires a specific degree and whether the applicant possesses the relevant degree and training, rather than the previous job title.

 Once an I-140 is approved and held for 180 days, the priority date is locked, and the applicant can extend an H-1B infinitely with any employer. To bridge a gap between roles, filing for a B-1 visa with an explicit intent of job hunting is a suggested strategy, rather than switching to an F-1 unless it represents a logical career progression.

The decision depends on the individual's tolerance for uncertainty. Staying on H-1B is generally safer for maintaining continuous employment authorization. Moving to H-4 EAD could lead to a break in authorization due to unpredictable USCIS processing times.

A standard practice is to include a notarized letter inside the new H-1B petition package. The letter should explicitly state that if the H-1B is approved with status, the pending B-2 should be withdrawn; otherwise, B-2 processing should continue.